| DE-FOA-0003612 | The Genesis Mission: Transforming Science and Energy with AI | 4/28/2026 05:00 PM ET | 12/17/2026 11:59 PM ET |
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Synopsis:
The DOE Office of Science (SC), Office of Critical Minerals and Energy Innovation (CMEI), Office of Environmental Management (EM), Office of Nuclear Energy (NE), Office of Electricity (OE), and Hydrocarbons and Geothermal Office (HGEO) hereby announce interest in receiving applications from interdisciplinary teams addressing the Genesis Mission National Science and Technology Challenges to accelerate scientific discovery and research and development (R&D) workflows using novel artificial intelligence (AI) models and frameworks. By achieving AI advantage, these teams will advance the DOE's mission and ensure America’s security and prosperity by addressing energy, environmental, and nuclear challenges through science and technology. Teams are encouraged to leverage the extensive scientific and data resources of the DOE/National Nuclear Security Administration (NNSA), the National Laboratories, U.S. industry, and academia. The resulting AI models and workflows, if successful, may be integrated into the American Science Cloud.
DOE is soliciting new FY26 Phase I small team and Phase II large team applications in the following topic areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy (see specific focus areas in Section III Program Descriptions).
In addition, this RFA will remain available to allow the recipients of FY26 Phase I awards to apply for larger team Phase II awards. In a few weeks, DOE plans to amend the RFA to clarify the LOI and application guidelines for FY26 Phase II awards. In FY27, DOE plans to amend the RFA or to issue an alternative funding opportunity to update the topic and focus areas to allow a second competition of Phase I small team applications and Phase II large team applications.
Additional applications for Phase I and Phase II may be submitted after the corresponding deadline listed on the cover of this RFA, however, DOE reserves the right to decline such applications without review.
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Program Name:
Office of the Deputy Director for Science Programs
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Fiscal Year:
2026
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| DE-FOA-0003600 | FY 2026 Continuation of Solicitation for the Office of Science Financial Assistance Program | 9/30/2026 11:59 PM ET | 10/1/2026 12:00 AM ET |
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Synopsis:
(Not Provided)
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Program Name:
Office of the Deputy Director for Science Programs
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Fiscal Year:
2026
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| DE-FOA-0003614 | Energy Frontier Research Centers (EFRCs) | 4/1/2026 05:00 PM ET | 7/1/2026 11:59 PM ET |
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Synopsis:
(Not Provided)
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Program Name:
Office of Basic Energy Sciences
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Fiscal Year:
2026
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| DE-FOA-0003602 | Early Career Research Program (ECRP) | 3/24/2026 11:59 PM ET | 6/2/2026 11:59 PM ET |
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Synopsis:
(Not Provided)
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Program Name:
Office of the Deputy Director for Science Programs
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Fiscal Year:
2026
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| DE-FOA-0003615 | Building EPSCoR-State/National Laboratory Partnerships | 3/18/2026 05:00 PM ET | 5/21/2026 11:59 PM ET |
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Synopsis:
The DOE SC Established Program to Stimulate Competitive Research (EPSCoR) hereby announces its interest in receiving applications for Building EPSCoR-State/DOE-National Laboratory Partnerships. These partnerships advance understanding of the physical world by supporting fundamental, early-stage energy research collaborations with the DOE National Laboratories. (Information on the DOE National Laboratories including links to websites can be found at https://www.energy.gov/about-national-labs.) Participation by undergraduate students, graduate students, or postdoctoral fellows is required. Early career faculty from EPSCoR jurisdictions are encouraged to apply. Utilization of DOE user facilities is encouraged. (Information on the SC User Facilities can be found at https://science.osti.gov/User-Facilities/User-Facilities-at-a-Glance; information on the DOE Office of Nuclear Energy user facilities can be found at https://nsuf.inl.gov).
DOE EPSCoR follows NSF EPSCoR Program eligibility determinations. As a result, and in accordance with 2 CFR 910.126, competition, eligibility for award is restricted. Domestic applicants except nonprofit organizations described in section 501(c)(4) of the Internal Revenue Code of 1986 that engaged in lobbying activities after December 31, 1995, that are within the following jurisdictions will be eligible to apply under this NOFO: Alabama, Alaska, Arkansas, Delaware, Guam, Hawaii, Idaho, Iowa, Kansas, Kentucky, Louisiana, Maine, Mississippi, Montana, Nebraska, Nevada, New Hampshire, New Mexico, North Dakota, Oklahoma, Puerto Rico, Rhode Island, South Carolina, South Dakota, Vermont, Virgin Islands, West Virginia, and Wyoming.
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Program Name:
Office of Basic Energy Sciences
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Fiscal Year:
2026
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| DE-FOA-0003620 | FY2026 Research Opportunities in Accelerator Stewardship and Accelerator Development | 4/9/2026 05:00 PM ET | 5/21/2026 11:59 PM ET |
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Synopsis:
The DOE SC program in High Energy Physics (HEP) hereby announces its interest in applications to conduct cross-cutting use-inspired basic research and development (R&D) to advance accelerator science and technology (AS&T) and domestic supplier development that supports SC’s activities in physical sciences research and which is of broader benefit to other U.S. government agencies and industry. Please note that this Notice of Funding Opportunity (NOFO) is for cross-cutting R&D and domestic supplier development and that program-specific AS&T R&D is supported though NOFOs issued by each SC program.
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Program Name:
Office of High Energy Physics
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Fiscal Year:
2026
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| DE-FOA-0003432 | FY 2025 Continuation of Solicitation for the Office of Science Financial Assistance Program | 9/29/2025 11:59 PM ET | 9/30/2025 11:59 PM ET |
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Synopsis:
The SC mission is to deliver scientific discoveries and major scientific tools to transform our understanding of nature and advance the energy, economic and national security of the United States. SC is the Nation’s largest Federal sponsor of basic research in the physical sciences and the lead Federal agency supporting fundamental scientific research for our Nation’s energy future.
SC accomplishes its mission and advances national goals by supporting:
• The frontiers of science—exploring nature’s mysteries from the study of fundamental subatomic particles, atoms, and molecules that are the building blocks of the materials of our universe and everything in it to the DNA, proteins, and cells that are the building blocks of life. Each of the programs in SC supports research probing the most fundamental disciplinary questions.
• The 21st Century tools of science—providing the Nation’s researchers with 28 state-of-the-art national scientific user facilities - the most advanced tools of modern science - propelling the U.S. to the forefront of science, technology development and deployment through innovation.
• Science for energy and the environment?paving the knowledge foundation to spur discoveries and innovations for advancing the Department’s mission in energy and environment. SC supports a wide range of funding modalities from single principal investigators to large team-based activities to engage in fundamental research on energy production, conversion, storage, transmission, and use, and on our understanding of the earth systems.
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Program Name:
Office of the Deputy Director for Science Programs
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Fiscal Year:
2025
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| DE-FOA-0003545 | EXPRESS: 2025 Exploratory Research for Extreme-Scale Science | 2/25/2025 05:00 PM ET | 5/6/2025 11:59 PM ET |
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Synopsis:
The DOE SC program in Advanced Scientific Computing Research (ASCR) hereby announces its interest in basic research to explore potentially high-impact approaches in scientific computing and extreme-scale science.
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Program Name:
Office of Advanced Scientific Computing Research
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Fiscal Year:
2025
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| DE-FOA-0003515 | Scientific Discovery through Advanced Computing (SciDAC): Partnerships in Basic Energy Sciences | 2/21/2025 05:00 PM ET | 4/25/2025 11:59 PM ET |
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Synopsis:
The DOE SC programs in Basic Energy Sciences (BES) and Advanced Scientific Computing Research (ASCR) announce their interest in receiving applications from interdisciplinary teams to establish partnerships under the Scientific Discovery through Advanced Computing (SciDAC) program in specific targeted topic areas that relate to the BES and ASCR missions. Targeted topics are described in the Supplementary Information section below.
This Announcement invites new research applications for the SciDAC Partnerships in BES that enable or accelerate scientific discovery employing DOE High-Performance Computing (HPC) facilities. For the purpose of this Announcement, the term “DOE HPC” has been expanded to include the high-performance production computational systems at the National Energy Research Scientific Computing Center (NERSC), the Argonne Leadership Computing Facility (ALCF), the Oak Ridge Leadership Computing Facility (OLCF), or similar DOE computing facilities. DOE HPC includes the exascale machines Frontier and Aurora.
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Program Name:
Office of Basic Energy Sciences
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Fiscal Year:
2025
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| DE-FOA-0003516 | Private Facility Research Program | 2/19/2025 11:59 PM ET | 4/23/2025 11:59 PM ET |
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Synopsis:
The DOE SC program in Fusion Energy Sciences (FES) hereby announces its interest in applications for a Private Facility Research (PFR) program to support public research utilizing world leading experimental capabilities owned by private companies. Along the path to constructing Fusion Pilot Plants (FPPs), many private fusion companies are constructing interim small-to-large scale research facilities to establish the scientific and/or technological basis for their chosen fusion concepts. Since the research on these interim facilities is largely foundational in nature, the mission overlap between the public and private sectors is large. Consistent with the FES Building Bridges Vision , the PFR program serves as a bridge from boldly delivered private sector hardware back to foundational research expertise residing in the public sector. Through the program, public researchers will conduct open peer-reviewed science at private facilities, to enhance the scientific rigor and breadth of the existing private efforts for the mutual benefit of all involved. As with all thriving high-tech industries, a strong connection to foundational research is essential.
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Program Name:
Office of Fusion Energy Sciences
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Fiscal Year:
2025
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| DE-FOA-0003450 | Early Career Research Program (ECRP) | 2/18/2025 05:00 PM ET | 4/22/2025 11:59 PM ET |
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Synopsis:
(Not Provided)
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Program Name:
Office of the Deputy Director for Science Programs
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Fiscal Year:
2025
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| DE-FOA-0003530 | Research, Development, and Training in Isotope Production | 2/17/2025 11:59 PM ET | 4/17/2025 11:59 PM ET |
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Synopsis:
Isotopes are high-priority commodities of strategic importance for the Nation and are essential in medical diagnosis and treatment, discovery science, national security, industrial processes, advanced manufacturing, space exploration, communications, biology, archaeology, quantum information science, clean energy, environmental science, and other fields. Isotopes can directly enable emerging technologies and contribute to the economic, technical, and scientific strength of the United States. The DOE Office of Science Program for Isotope R&D and Production (also referred to as the DOE Isotope Program or DOE IP) routinely funds research and development (R&D) in isotope science to advance fundamental understanding and develop cutting edge and efficient technologies for enriching, producing, processing, recycling, and purifying radioactive and stable isotopes in short supply. This Notice of Funding Opportunity (NOFO) is narrowly focused on topics involving AI/ML, enhanced processing chemistry used in matter phase changes, and separation science. Applications incorporating effective ways to train the next generation of personnel with essential knowledge and skills related to the production, processing, and purification of radioactive and enriched stable isotopes are strongly encouraged.
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Program Name:
Office of Isotope R&D and Production
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Fiscal Year:
2025
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| DE-FOA-0003503 | Research in Basic Plasma Science and Engineering | 2/14/2025 05:00 PM ET | 4/4/2025 11:59 PM ET |
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Synopsis:
The DOE SC program in Fusion Energy Sciences (FES) hereby announces its interest in receiving new or renewal single-investigator or small-group applications to carry out hypothesis-driven frontier-level research in basic plasma science and engineering. The FES Discovery Plasma Science: Plasma Science and Technology–General Plasma Science (GPS) program supports research at the frontiers of basic plasma science (including astrophysical, dusty, and low temperature plasma). GPS topical areas are broad and include but are not limited to: understanding the onset of magnetic reconnection and trigger mechanisms for explosive instabilities in nature (solar flares, geomagnetic storms) and in the laboratory; magnetic dynamo processes by which magnetic fields are generated in laboratory and astrophysical plasmas; mechanisms by which energy is transferred between fields, flows, and particles; how coherent structures are created through the self-fields of the plasma and its interactions with waves; coupling of dusty plasma in strong magnetic fields; and plasma chemistry and processes related to interaction of plasma with surfaces, materials, or biomaterials. Through the support of this research, the GPS program plays a key role in training the next generation of plasma scientists and engineers.
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Program Name:
Office of Fusion Energy Sciences
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Fiscal Year:
2025
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| DE-FOA-0003526 | High-Energy-Density Laboratory Plasma Science | 1/30/2025 05:00 PM ET | 3/27/2025 11:59 PM ET |
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Synopsis:
The DOE SC program in Fusion Energy Sciences (FES) and the NNSA Defense Program (DP) Office of Experimental Sciences jointly announce their interests in receiving applications for new and renewal awards for research in High-Energy-Density Laboratory Plasma Science. All individuals or groups planning to submit applications for new or renewal funding in Fiscal Year 2025 should do so in response to this Notice of Funding Opportunity (NOFO). This NOFO is part of the SC-NNSA Joint Program in High-Energy-Density Laboratory Plasmas, a partnership aimed at advancing fundamental high-energy-density science within the DOE.
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Program Name:
Office of Fusion Energy Sciences
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Fiscal Year:
2025
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| DE-FOA-0003453 | Systems Biology Research to Advance Bioenergy Crop Production | 1/17/2025 05:00 PM ET | 3/26/2025 11:59 PM ET |
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Synopsis:
(Not Provided)
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Program Name:
Biological Systems Science
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Fiscal Year:
2025
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