This work seeks to address fundamental issues related to how the application of nanosecond electrical pulses affect the generated plasma properties and how these plasma properties in turn influence chemical reactions in the gas, liquid, and interface in reactors where plasma is in contact with liquid water surfaces. The work will also determine how the plasma chemistry influences inactivation of microbial species that are resistant to hydrogen peroxide, a major disinfectant produced in plasma liquid-water interactions. Previous work has shown that the variation of the pulse parameters (rise-time, pulse width, input voltage) and frequency in a uniformly pulsed system can influence the production rates, energy yields/efficiencies of various chemical reactions occurring in the reactor through changing the plasma properties (e.g., plasma gas temperature, electron density, electron energy). Previous work has also shown that variation of the mode of delivery of the nanosecond high voltage pulses using sequences of bursts of pulses can affect the degradation of organic compounds fully soluble in the liquid phase, while not affecting the generation of hydrogen peroxide. The proposed work seeks to determine why and how the nature of the pulse delivery, i.e., through sequences of bursts of high voltage pulses, affect the plasma properties, the induced gas and liquid chemical reactions, and the inactivation of microorganisms. The fundamental knowledge gained in the proposed research will provide insight into reactions in low temperature plasma contacting liquid water that are currently under investigation or being used in a wide range of chemical, environmental, materials, and biomedical engineering applications.